Approved for Metastatic colorectal cancer (first-line in combination with 5-FU/leucovorin, or second-line as monotherapy), Various solid tumors in combination regimens. Converted to its active metabolite SN-38, which binds to the topoisomerase I-DNA complex, preventing religation of single-strand DNA breaks during replication, leading to double-strand breaks and… Side effects, costs,…
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